Oraxin Syrup


Oraxin Syrup is a combination of three medicines: Cyproheptadine, tricholine citrate and sorbitol, which revives appetite. Cyproheptadine is an appetite-stimulant. It works by reducing the effect of a chemical messenger (serotonin) in the hypothalamus, a part of the brain which regulates appetite. Tricholine citrate is a bile acid binding agent which removes bile acids from the body. The liver then produces more bile acids using cholesterol, as a result of which cholesterol level is lowered. Sorbitol acts as a syrup base and also as an osmotic laxative to relieve constipation.

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Each ml of ORAXIN Drops contains:
Cyproheptadine hydrochloride 1.5mg
Tricholine citrate 55 mg

Cyproheptadine is a serotonin and histamine antagonist with sedative property. It finds clinical application in stimulating the appetite and growth. The appetite stimulating effect of cyproheptadine is probably a consequence
of serotonin antagonism. It antagonizes the satiety stimulating effects of serotonin on the satiety center. Weight gain and increased growth in children that have been observed with cyproheptadine can be attributed to an
interference with regulation of the secretion of growth hormone.
Tricholine citrate contains three molecules of choline. Clinical interest in choline centers on its lipotropic action & its utility in the treatment of fatty infiltration and cirrhosis of liver. Choline converts fat into phospholipids like, lecithin, which is ssential to biomembrane structure and its function.
Lecithin is also a major component of high density lipoprotein (HDL), and is used to mobilize cholesterol from cell membrane. In patients with fatty liver, increased rate of phospholipid turnover has been observed following
administration of choline.

ORAXIN is indicated for loss of appetite, weight loss, anorexia nervosa, and as an adjunct to anti-tubercular and antiretroviral regimens for weight gain.
In children, ORAXIN is indicated in underweight children who have inadequate dietary intake or loss of appetite and children suffering from anemia, liver or digestive disorder.

Use of ORAXIN is contraindicated in newborn or premature infants. Other contraindications to ORAXIN include hypersensitivity to any ingredient of formulation, angle-closure glaucoma, stenosing peptic ulcer, symptomatic
prostatic hypertrophy, bladder neck obstruction and pyloroduodenal obstruction.

Cyproheptadine has an atropine-like action therefore, should be used with caution in patients with history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease and hypertension.
Antihistamines may diminish mental alertness; conversely, particularly, in the young child, they may occasionally produce excitation. Patients should be warned about engaging in activities requiring mental alertness and motor
coordination. Overdose of antihistamines, particularly in infants and children, may
produce hallucinations, central nervous system depression, convulsions and death. Antihistamines are more likely to cause dizziness, sedation and hypotension in elderly.

Pregnancy & Lactation
Because of the higher risk of antihistamines in newborns and prematures, antihistamine therapy is contraindicated in nursing mothers.

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